theaflavin-3,3'-digallate
| Name | Theaflavin 3,3'-digallate | ||
| PubChem CID | 21146795 | ||
| Molecular Weight | 868.7g/mol | ||
| Synonyms |
theaflavin-3,3'-digallate |
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| Formula | C₄₃H₃₂O₂₀ | ||
| SMILES | C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC4=C(C(=C(C=C4C5C(CC6=C(C=C(C=C6O5)O)O)O)O)OC(=O)C7=CC(=C(C(=C7)O)O)O)C(=O)C(=C3)OC(=O)C8=CC(=C(C(=C8)O)O)O)O | ||
| InChI | 1S/C43H32O20/c44-17-7-23(46)21-12-29(52)39(60-32(21)9-17)14-1-19-20(40-30(53)13-22-24(47)8-18(45)10-33(22)61-40)11-31(54)41(63-43(59)16-4-27(50)37(56)28(51)5-16)35(19)38(57)34(6-14)62-42(58)15-2-25(48)36(55)26(49)3-15/h1-11,29-30,39-40,44-56H,12-13H2/t29-,30-,39-,40-/m1/s1 | ||
| InChIKey | FJYGFTHLNNSVPY-BBXLVSEPSA-N | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | Cha | ||
| Use Part | Tender leaf or tender bud | ||
| Habitat | JiangSu, AnHui, ZheJiang, JiangXi, HuBei, SiChuan, GuiZhou, YunNan, Shaanxi | ||
| Flavor | Sweet; Bitter | ||
| Meridian Tropism | Lung; Stomach; Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ericales
-->Family: Theaceae
-->Genus: Camellia
-->Species: Camellia sinensis
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| Pair Name | Theaflavin 3,3'-digallate, Trastuzumab | |||
| Partner Name | Trastuzumab | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Mitosis | |||
| Gene Regulation | Down-regulation | Expression | SHCBP1 | hsa79801 |
| Down-regulation | Phosphorylation | MISP | hsa126353 | |
| Down-regulation | Expression | PLK1 | hsa5347 | |
| In Vitro Model | NCI-N87 | Gastric tubular adenocarcinoma | Homo sapiens (Human) | CVCL_1603 |
| HGC-27 | Gastric carcinoma | Homo sapiens (Human) | CVCL_1279 | |
| MKN45 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0434 | |
| AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 | |
| KATO II | Down syndrome | Homo sapiens (Human) | CVCL_M882 | |
| Hs 746.T | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0333 | |
| HEK293T | Healthy | Homo sapiens (Human) | CVCL_0063 | |
| SNU-216 | Gastric tubular adenocarcinoma | Homo sapiens (Human) | CVCL_3946 | |
| Result | These findings suggest an aberrant mitotic HER2-SHCBP1-PLK1 axis underlies trastuzumab sensitivity and offer a new strategy to combat gastric cancer. | |||
| Pair Name | Theaflavin 3,3'-digallate, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G1/S phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP7 | hsa840 | |
| In Vitro Model | A2780/CP70 | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_0135 |
| OVCAR-3 | High grade ovarian serous adenocarcinoma | Homo sapiens (Human) | CVCL_0465 | |
| Result | TF3 may be used as an adjuvant for the treatment of advanced ovarian cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer. Nat Commun. 2021 May 14;12(1):2812. doi: 10.1038/s41467-021-23053-8. | Click |
| 2 | Synergistic effect of black tea polyphenol, theaflavin-3,3'-digallate with cisplatin against cisplatin resistant human ovarian cancer cells. J Funct Foods. 2018 Jul;46:1-11. doi: 10.1016/j.jff.2018.04.037. | Click |
